Ionization for CE/MS
Capillary electrophoresis (Capillary electrophoresis (CE) offers short analysis times and high separation efficiencies for a wide range of compounds. The combination of CE and mass spectrometry has been used successfully to analyze proteins and a wide range of other compounds in complex sample matrices.
A specialized CE nebulizer is available to interface a CE system to Agilent LC/MS systems. It is most commonly used with the standard electrospray source, but can also be used with APCI, multimode, and APPI ion sources. No modification of the source is required; you retain all the benefits of orthogonal nebulization and counterflow drying gas. The CE nebulizer operates at ground potential, making CE separation conditions and MS operating conditions independent.